Toxic effects of butylated hydroxytoluene in rats

This study aimed to assess the acute toxicity in rats of heated and un heatedbutylated hydroxytoluene (BHT). Sunflower oil dissolved BHT, at 98±2ºC by a water bath. The animals were divided into five groups. control group dosage orally with sunflower oil, first treated 250 mg/kg second heated, BHT third 500 fourth BHT. All groups received oral treatment. results showed substantial reduction motor activity relative other dose There was distinction negative geotaxis test un-heated while cliff avoidance heat observed compared A significant occurred all pocketing dorsal tonic immobility test. pathological changes more severe than those especially It represented coagulative necrosis, muscle atrophy heart, interstitial pneumonia, serofibrinous exudate, pulmonary emphysema lung neuronal degeneration, microgliosis, myelin vacuolation satellitosis brain. concluded that had toxic effects neurobehavioral activity, histopathological brain, lung.